Humanistische Betrachtungen und Gegenwart

A note on "HIV-associated microangiopathy as a multiscale theory-net: A Sneed-Stegmüller structuralist reconstruction (from retinal cotton-wool spots and sludging to ADAMTS13) - A first look" by Stefan Geier et al. A field divided by its own vocabulary The manuscript is unusual in the best sense. It begins from a problem that is easy to underestimate: the same expression— HIV-associated microangiopathy —has been used for retinal cotton-wool spots, conjunctival sludging, neuroretinal dysfunction, cerebral perfusion abnormalities, coronary microvascular dysfunction, renal thrombotic microangiopathy, and immune thrombotic thrombocytopenic purpura. These phenomena share a vascular family resemblance, but they are not interchangeable observations, mechanisms, diagnoses, or therapeutic targets. A conventional narrative review can catalogue this diversity; it cannot, by itself, determine which cases belong to the same explanatory structure. 1 The paper’s answer— disciplined pluralis...

Chikungunya virus genome fits FIBONACCI- and LUCAS-numbers very well - a first look by Stefan Geier et al. Chikungunya virus (CHIKV) is an enveloped, positive-sense, single-stranded RNA virus (family Togaviridae , genus Alphavirus ) first isolated in Tanzania in 1953. Measuring 50–70 nm in diameter, the virus features an icosahedral capsid and belongs to the Semliki Forest virus complex, with close phylogenetic ties to the O'nyong'nyong and Ross River viruses. As an arbovirus transmitted by Aedes mosquitoes ("Asian" tiger mosquito or forest mosquito), CHIKV poses significant public health risks; consequently, it is classified as a Category B priority pathogen in the United States, necessitating Biosafety Level 3 (BSL-3) protocols for laboratory handling. Gene 1 length; non-structural proteins: 2474 nt* Gene 2 length; structural proteins: 1248 nt* Total gene length: 11700 nt* Nearest FIBNACCI- or LUCAS-numbers**: Gene 1: 2584 = F18  Gene 2: 1346 = L15 Full gene: 10946...