A note on "HIV-associated microangiopathy as a multiscale theory-net: A Sneed-Stegmüller structuralist reconstruction (from retinal cotton-wool spots and sludging to ADAMTS13) - A first look" by Stefan Geier et al.
A note on "HIV-associated microangiopathy as a multiscale theory-net: A Sneed-Stegmüller structuralist reconstruction (from retinal cotton-wool spots and sludging to ADAMTS13) - A first look" by Stefan Geier et al. A field divided by its own vocabulary The manuscript is unusual in the best sense. It begins from a problem that is easy to underestimate: the same expression— HIV-associated microangiopathy —has been used for retinal cotton-wool spots, conjunctival sludging, neuroretinal dysfunction, cerebral perfusion abnormalities, coronary microvascular dysfunction, renal thrombotic microangiopathy, and immune thrombotic thrombocytopenic purpura. These phenomena share a vascular family resemblance, but they are not interchangeable observations, mechanisms, diagnoses, or therapeutic targets. A conventional narrative review can catalogue this diversity; it cannot, by itself, determine which cases belong to the same explanatory structure. 1 The paper’s answer— disciplined pluralis...