Ghrelin "hunger" peptide fits GEIER's equations with 97% by the 7th LUCAS-number

The Ghrelin "hunger" peptide fits GEIER's equations with 97% by the 7th LUCAS-number - A first look

by Stefan Geier et al.

GHRELIN is a peptide hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is also identified as "the" "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after food intake. Ghrelin may help prepare for mealtimes by increasing gastric motility, and stimulating the secretion of gastric acid.

The legth of the petide is 28 aminoacids*.
We looked for the nearest FIBONACCI- or LUCAS-number** for the Ghrelin protein legth. The nearest of those numbers is 29 = the 7th LUCAS-number.

The fit is 28/29=0.965517~97%.
This corroborates GEIER's equations and GEIER's programme** at an actual point of scientific, and clinical medical interest.


*Wikipedia, today: https://en.wikipedia.org/wiki/Ghrelin ; Seim I, Amorim L, Walpole C, Carter S, Chopin LK, Herington AC (January 2010). "Ghrelin gene-related peptides: multifunctional endocrine / autocrine modulators in health and disease". Clinical and Experimental Pharmacology & Physiology. 37 (1): 125–131. doi:10.1111/j.1440-1681.2009.05241.x. PMID 19566830. S2CID 21657818.

**St. Geier et al. "GEIER's Equations" and "GEIER's Φ(e) ↔ Φ(α) Equilibrium Programme" with FIBONACCI/LUCAS extensions (GEIER's Equations Part 2.1). ResearchGate, February 2026, DOI: 10.13140/RG.2.2.33185.67689.

...

Yours, Stefan Geier
Gerhart-Hauptmann-Strasse 6
83071 Haidholzen

Motivated by OVB

Additum 1: 

Comparable considerations hold for Glucagon-like peptide-1 (GLP-1) with a length of 30 to 37 aa with the 9th FIBONACCI-number 34 at the center of the isoforms lengths (Wikipedia today: https://en.wikipedia.org/wiki/Glucagon-like_peptide-1):

Source

PubChem

URL

https://pubchem.ncbi.nlm.nih.gov

Additum 2:

Selected fixed endpoints and sensitivity classifications

Endpoint	Observed	Exact F/L	Nearest F/L	Distance	m≤10 within 5%
Genomic span	7282 bp	No	6765 (Fibonacci)	7.10%	Yes
Canonical mRNA length	1434 nt	No	1364 (Lucas)	4.88%	Yes
Total exon count	6 exons	No	5 (Fibonacci)	16.67%	Yes
Coding exon count	4 exons	Yes	4 (Lucas)	0.00%	Yes
Preproghrelin length	117 aa	No	123 (Lucas)	5.13%	Yes
Signal peptide length	23 aa	No	21 (Fibonacci)	8.70%	Yes
Ghrelin-28 length	28 aa	No	29 (Lucas)	3.57%	Yes
Obestatin candidate peptide length	23 aa	No	21 (Fibonacci)	8.70%	Yes
Acylated serine position in mature ghrelin	3 position	Yes	3 (Fibonacci and Lucas)	0.00%	Yes
Same acylated serine in precursor coordinates	26 position	No	29 (Lucas)	11.54%	Yes
Dominant octanoyl chain length	8 carbons	Yes	8 (Fibonacci)	0.00%	Yes
Observed decanoyl chain length	10 carbons	No	11 (Lucas)	10.00%	Yes

Additum 3 (3 hours later):

Glucagon fits with 29 aa the 7th LUCAS-number with 100%. (https://en.wikipedia.org/wiki/Glucagon : Unger RH, Orci L (June 1981). "Glucagon and the A cell: physiology and pathophysiology (first two parts)". The New England Journal of Medicine. 304 (25): 1518–24. doi:10.1056/NEJM198106183042504. PMID 7015132.)
This substantially corroborates the above and GEIER's equations and GEIER's programme** at an actual point of scientific, and clinical medical interest.

#Wegovy #Ozempic #Rybelsus