Gastric inhibitory polypeptide (GIP) fits a LUCAS-FIBONACCI-midpoint with about 96.4% and thus corroborates Geier's equations and equilibrium concept; Tirzepatide fits with 87% to F9 and the same LUCAS-FIBONACCI-number-midpoint with about 96.3% - A first look by Stefan Geier et al.

Gastric inhibitory polypeptide (GIP) fits a LUCAS-FIBONACCI-number-midpoint with about 96.4% and thus corroborates Geier's equations and equilibrium concept; Tirzepatide fits with 87% to F9 and the same LUCAS-FIBONACCI-number-midpoint with about 96.3% - A first look

by Stefan Geier et al.

Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones. While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion.

GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins, which stimulate insulin release on oral food intake.

Tirzepatide is an analog of the human GIP hormone with a C20 fatty diacid portion attached, that has been approved for treatment of diabetes in the US in May 2022.

The legth of the GIP peptide is 42 amino acids*.

We looked for the nearest FIBONACCI- or LUCAS-number or midpoint** for the GIP protein legth. The nearest of those numbers are F9=34 and L8=47.

The midpoint fit is (34+47)/2/42=40.5/42=0.96429 ~ 96%.
This corroborates GEIER's equations and GEIER's programme** at an actual point of scientific, and clinical medical interest.

Tirzepatide has ~39 aa with a C20 fatty diacid portion attached***; a 87% fit to F9 for the peptide component. The midpoint fit to the F9-L8-midpoint is 39/40.5~0.96296 ~ 96%. Hypothesis: Optimization to F9 or the F9-L8-midpoint to reduce adverse effects is putative possible.

For comparison:
Semaglutid: 32 aa; 98.4% fit to a 31.5 L7-F9-midpoint.****
Dulaglutid: 31 aa; 98.4% fit to a L7-F9-midpoint.*****

All drugs for "weight reduction" described here are engineered in a way that fits our equlibrium criteria.

*Wikipedia, today: https://en.wikipedia.org/wiki/Gastric_inhibitory_polypeptide .

**St. Geier et al. "GEIER's Equations" and "GEIER's Φ(e) ↔ Φ(α) Equilibrium Programme" with FIBONACCI/LUCAS extensions (GEIER's Equations Part 2.1). ResearchGate, February 2026, DOI: 10.13140/RG.2.2.33185.67689.
***Wikipedia, today: https://de.wikipedia.org/wiki/Tirzepatid .
****https://de.wikipedia.org/wiki/Semaglutid .
*****https://de.wikipedia.org/wiki/Dulaglutid .

...

3D structure of gastric inhibitory polypeptide (GIP) using PDB 2obu data. Ref: Alana, I., Malthouse, J.P.G., O`harte, F.P.M., Hewage, C.M. (2007) The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy Proteins 68: 92-99; Wikipedia today .

Wikipedia, today:

Description	English: Tirzepatide in 3 letter code
Date	19 November 2023
Source	Own work
Author	Benff

Yours, Stefan Geier
Gerhart-Hauptmann-Strasse 6
83071 Haidholzen

Motivated by Katharina Geier (reported a putative adverse effect related necrotizing myositis, immune-mediated necrotizing myopathy IMNM, for Tirzepatide). As described above (mid-point fit of 96%) peptide length is not to be expected as cofactor for adverse effects of Tirzepatide.

Additum 1: 

Comparable considerations hold for Glucagon-like peptide-1 (GLP-1) with a length of 30 to 37 aa with the 9th FIBONACCI-number 34 at the center of the isoforms lengths (Wikipedia today: https://en.wikipedia.org/wiki/Glucagon-like_peptide-1):

Source

PubChem

URL

https://pubchem.ncbi.nlm.nih.gov

Additum 2:

Selected fixed endpoints and sensitivity classifications

Endpoint	Observed	Exact F/L	Nearest F/L	Distance	m≤10 within 5%
Genomic span	7282 bp	No	6765 (Fibonacci)	7.10%	Yes
Canonical mRNA length	1434 nt	No	1364 (Lucas)	4.88%	Yes
Total exon count	6 exons	No	5 (Fibonacci)	16.67%	Yes
Coding exon count	4 exons	Yes	4 (Lucas)	0.00%	Yes
Preproghrelin length	117 aa	No	123 (Lucas)	5.13%	Yes
Signal peptide length	23 aa	No	21 (Fibonacci)	8.70%	Yes
Ghrelin-28 length	28 aa	No	29 (Lucas)	3.57%	Yes
Obestatin candidate peptide length	23 aa	No	21 (Fibonacci)	8.70%	Yes
Acylated serine position in mature ghrelin	3 position	Yes	3 (Fibonacci and Lucas)	0.00%	Yes
Same acylated serine in precursor coordinates	26 position	No	29 (Lucas)	11.54%	Yes
Dominant octanoyl chain length	8 carbons	Yes	8 (Fibonacci)	0.00%	Yes
Observed decanoyl chain length	10 carbons	No	11 (Lucas)	10.00%	Yes

Additum 3:

Glucagon fits with 29 aa the 7th LUCAS-number with 100%. (https://en.wikipedia.org/wiki/Glucagon : Unger RH, Orci L (June 1981). "Glucagon and the A cell: physiology and pathophysiology (first two parts)". The New England Journal of Medicine. 304 (25): 1518–24. doi:10.1056/NEJM198106183042504. PMID 7015132.)
This substantially corroborates the above and GEIER's equations and GEIER's programme** at an actual point of scientific, and clinical medical interest.

Additum 4, 05.08.2026:

Figure 1. Local Fibonacci, Lucas, and adjacent Fibonacci-Lucas midpoint targets together with the five-candidate 39-40-residue cluster and biological comparators. The shaded interval marks integer lengths 39-42, which reach at least 96% proximity to the prespecified midpoint 40.5. 
(August 2026, DOI: 10.13140/RG.2.2.15528.33289 )

#Wegovy #Ozempic #Rybelsus #Mounjaro