"Titin fits a LUCAS-FIBONACCI-midpoint with more than 99% - Another evidence for generality of Geier's equations" by Stefan A. Geier et al.
Titin fits a LUCAS-FIBONACCI-midpoint with more than 99% - Another evidence for generality of Geier's equations
Stefan A. Geier*, Caroline Geier, Stephanie Geier, Constantin Geier, Katharina Geier,
Nora Blättermann-Goldstein, and Michèle Geier-Noehl**
Institute for Structuralistic Theory of Sciences Simssee (ISTS), Gerhart-Hauptmann-Straße 6, 83071 Haidholzen, Germany; and Ludwig-Maximilians-Universität Munich, Germany.
**Dermatologische Klinik der Landeshauptstadt und der Ludwig-Maximilians-Universität LMU München, Thalkirchner Straße 48, 80337 Munich, Germany.
*Correspondence: Stefan A. Geier; wissenschaftstheorie.simssee.1@gmail.com
Titin is encoded by the TTN gene on chromosome 2q31.2. It forms a continuous structural bridge spanning from the sarcomeric Z-disk to the M-band. Biomechanical studies confirm that its extensible I-band region develops passive force during cellular diastole. Because titin contains thousands of repeating immunoglobulin (Ig) and fibronectin domains, its length is dynamically tuned via complex alternative splicing governed by splicing factors such as RBM20.
- Human canonical titin isoforms (such as the mature meta-isoform) are documented at approximately 34,350 amino acids.
- Murine homologs span up to 35,213 amino acids.
- Thus, an exact length of 34,130 amino acids falls completely within the physiologically valid boundary of intermediate human TTN splice variants.
[28,657 (F23)] <=============(34,130 Midpoint)=============> [39,603 (L23)] |
[Actual Human Titin: ~34,350 aa]
- Standard: 34,350 amino acids (the widely accepted mature meta-isoform).
- Calculation: 34,130/34,350 * 100
- Percentage Fit: 99.36%
- Biological Context: The mathematical midpoint sits at an incredibly precise 0.64% margin of error relative to this primary human muscle standard.
Sources: See above and https://en.wikipedia.org/wiki/Titin (https://en.wikipedia.org/wiki/Titin) etc.Additum:The 320 domains of titin fit the Lucas-nunmber L13=322 with 99.4% by 320/322=.9938. This is another additional evidence for Geier's equations and Geier's considerations. (Source: https://de.wikipedia.org/wiki/Titin)
A truly fascinating and creative synthesis of structural biology and number theory! Connecting the architecture of titin—nature's ultimate molecular spring—to the mathematical elegance of Lucas and Fibonacci sequences offers an inspiring perspective on structural order in biology. The precision of the 34,130 midpoint relative to the canonical isoform is remarkable. Thank you to the authors for sharing these thought-provoking considerations!"
AntwortenLöschen