A comment on the Nobel Prize in Physiology or Medicine, in Physics, and in Chemistry 2024: AlphaFold, RNA Intelligence and AI

A comment on the Nobel Prize in Physiology or Medicine, in Physics, and in Chemistry 2024: AlphaFold, RNA Intelligence and AI

My Warmest Congratulations for being awarded the 2024 Nobel Prize in Chemistry to David Baker “for computational protein design” and to Demis Hassabis and John M. Jumper “for protein structure prediction.”

May I note that my comment on RNA intelligence and AI from yesterday morning* is able to explain the enormous efficacy of AlphaFold2 at least in part.

My argumentation is as follows:

1. microRNA is a very important component of protein synthesis.

2. microRNA evolution is related to backpropagation*.

3. Backpropagation is a very important factor in the neural network AlphaFold uses based on proteins which are based on RNA and microRNA regulation.

4. AlphaFold2 uses the same or nearly the same principles RNA or microRNA respective RNA or microRNA evolution use.

5. AlphaFold2 computation gains an efficacy bewteen 80% and 90% in protein folding.

Additum:
Φ (Golden Ratio) and its relation to the elementary charge e, Arnold SOMMERFELD’s alpha, and Max PLANCK’s constant h = 2ℏ * pi [1] allow an additional argumentation in the same direction: Neural networks should extract this relation in hidden layers. Emperical testing of this hypothesis should be possible.

Yours Stefan Geier
Gerhart Hauptmann Straße 6
83071 Haidholzen, Germany

#nobelprize2024 #NobelPrize #alphafold #KI #AI #artificialintelligence #protein #proteins

*https://humanistischebetrachtungen1.blogspot.com/2024/10/a-comment-on-both-nobel-prize-in.html

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[1] https://www.researchgate.net/publication/381659767_Coiled_Coil_Helices_Including_Alpha-Keratin_and_Leucine_Zippers_are_Related_to_the_Golden_Ratio_Concept_by_the_Omega_Constant_O_and_are_Related_to_Tetrahedra_Helices_and_to_Quantum_Physics?utm_source=twitter&rgutm_meta1=eHNsLXJ1OXdzR3Mwc2ZRRTJVSXEzN2ZwNHQ1dEQ2MXRFcWtSLzAxMENLenNoSCtKYzJrNFROcGJCaFd2UEN2dmFVc3BJZ1VXSUpqQXVDak9wdlBCWnpTam9aVT0%3D