microRNA, FIBONACCI numbers, Quantum Physics, and Phi: A Very Good Fit

microRNA, FIBONACCI numbers, Quantum Physics, and Phi: A Very Good Fit

Heartfelt Congratulations to Victor Ambros and Gary Ruvkun for being awarded the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation from Germany.

It's noteworthy that the lin-4 microRNA is 21

nucleotides (bases, "base pairs") long and 21 is a FIBONACCI number (F8) and thus the microRNA concept is (strictly) consistent with our considerations below.

(Please, note furthermore that with the LUCAS numbers 18 and 29 we get {F(8) + [L(7) + L(8)]/2}/2 = {21 + [18 +29]/2}/2 = {21 + 23.5}/2 = = 22.25 (nt, nucleotides, "base pairs") being a good approximation for the microRNA length of more advanced organisms. Please, compare with the concepts of complexity gains in evolution. A very good fit to our considerations below, too.)

Yours Stefan Geier, Haidholzen Additum 14.10.2024: With L(7) = 18 and [L(7) + L(8)] /2 = 23.5 we get good boundaries “18 to 24” [24 near to 23.5 and see (ii) below] for the microRNA length; however, biology allows a high open variability compared to physics and mathematics, and thus we should not be disturbed by finding a mature microRNA longer than 24 nt. An upper last relative maximum should be the LUCAS number L(8) = 29.

Including the winding number perspective of nucleic acids the number 22 should be a preferred length as it is (i) the natural number next to 22.25 and (ii) twice the winding number 11 for the RNA-A double helix: 2 * 11 nt = 22 nt. Look, that we find the factor 2 here, again. As 12 is the winding number of the less frequent RNA-A’ double helix we should also look at the number 24 (nt) as a relevant expected value for microRNA length in special conditions.

#NobelPrize #NobelPrize2024 #NobelPrizePhysiology #microRNA

MLA style: Advanced information. NobelPrize.org. Nobel Prize Outreach AB 2024. Mon. 7 Oct 2024. <https://www.nobelprize.org/prizes/medicine/2024/advanced-information/> Hi: My research is available on @ResearchGate: https://www.researchgate.net/publication/381659767_Coiled_Coil_Helices_Including_Alpha-Keratin_and_Leucine_Zippers_are_Related_to_the_Golden_Ratio_Concept_by_the_Omega_Constant_O_and_are_Related_to_Tetrahedra_Helices_and_to_Quantum_Physics?utm_source=twitter&rgutm_meta1=eHNsLXJ1OXdzR3Mwc2ZRRTJVSXEzN2ZwNHQ1dEQ2MXRFcWtSLzAxMENLenNoSCtKYzJrNFROcGJCaFd2UEN2dmFVc3BJZ1VXSUpqQXVDak9wdlBCWnpTam9aVT0%3D